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Welcome to the Benninger Lab

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The Benninger lab is a multi-disciplinary team of scientists who are guided by engineering principles and technologies to study the endocrine pancreas (islets of Langerhans).  With mechanistic knowledge underlying the dynamics of islet function and hormone release, we can develop diagnostics and therapeutic interventions to effectively manage, cure and prevent diabetes. Towards this goal the lab combines novel optical imaging and ultrasound imaging approaches to study the function of the islets of Langerhans over multiple levels of organization, and how function is disrupted in diabetes.
Our research includes:
  • Systems biophysics of the islet of Langerhans in diabetes
  • Electrical synapse (gap junction channel) plasticity
  • Cell heterogeneity and emergent multicellular properties of the islet
  • Advanced optical microscopy and ultrasound imaging
  • Imaging diagnostics for type 1 diabetes
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Cellular networks and emergent behavior

We utilize optical imaging and computer models to understand the role of electrical coupling networks and functional sub-populations of cells in affecting the timing and response of hormone secretion within the islets of Langerhans
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Molecular mechanisms of diabetes pathogenesis

 We are examining molecular mechanisms of dysfunction to the islets of Langerhans in both type1 and type2 diabetes. Through this, we aim to discover novel targets for therapeutic treatment.
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Ultrasound-based imaging diagnostics

We develop and apply novel ultrasound contrast agents and imaging methods for the early diagnosis of type1 diabetes and to track diabetes progression and reversal. We are also developing imaging guided drug delivery approaches for the targeted therapeutic reversal of diabetes

Positions open

We are a highly multidisciplinary lab, whose members have backgrounds in physics, maths, engineering, computer science, biochemistry, physiology. A key mission of our lab is to provide a rewarding training environment to allow researchers to gain new skills and perspectives. Even if no specific openings are described below, please feel free to stop by the lab or email Dr Benninger to discuss options for projects and research training. 

​We have an open position for a PhD student or postdoctoral fellow to work on developing novel ultrasound contrast agents for diagnosis of type1 diabetes ands for therapeutic delivery. An excellent opportunity for training in ultrasound imaging, diabetes, and clinical-translational research

​A number of research projects are available in our group for MS students involving islet or pancreas imaging. 
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Our lab is within the Barbara Davis center; a world leading diabetes center which provides state-of the-art care to children and adults with type 1 diabetes.

Barbara Davis center
1775 Aurora Ct. 
Aurora CO. 80045
(303) 724-6388
​richard.benninger@cuanschutz.edu

Come and see our lab's work!
Note: Owing to the Coronavirus pandemic, these talks have been postponed to a later date.  Please check back at a later date. Stay safe everyone.

21st Apr. '20

IPITA/JDRF/HSCI Stem-cell derived Beta cell conference

Boston, MA
​Richard Benninger will present 'Mapping beta cell heterogeneity and cross talk within the human islet'
 

21st May '20

Imperial College London

London, UK
​Richard Benninger will present 'Gap junction channels, cellular heterogeneity and the regulation of insulin secretion dynamics'

14th June '20

ADA scientific sessions 

Chicago, IL
​Richard Benninger will present 'Novel Imaging Techniques to Detect Islet Inflammation' 
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