Cell heterogeneity, cellular 
networks and emergent multi-cellular behavior

We utilize optical imaging, computer models and novel fluorescent reporters to understand the role of functional sub-populations and cellular networks in affecting the timing and response of hormone secretion within the islets of Langerhans. This includes novel mouse models and human pancreas tissue platforms

Molecular mechanisms of diabetes pathogenesis
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We are examining molecular mechanisms of dysfunction to the islets of Langerhans in both type 1 and type 2 diabetes. Through this, we aim to discover novel targets for therapeutic treatment. A major focus is understanding the transcriptional and posttranslational regulation of gap junction channels (electrical synapses)

Ultrasound-based imaging 
​diagnostics and Islet microvasculature

We develop and apply novel ultrasound contrast agents and imaging methods for the early diagnosis of type 1 diabetes and to track diabetes progression and reversal. This includes understanding changes to the structure and function of the islet microvasculature in diabetes

Positions open

We are a highly multidisciplinary lab, whose members have backgrounds in physics, maths, engineering, computer science, biochemistry, physiology. A key mission of our lab is to provide a rewarding training environment to allow researchers to gain new skills and perspectives. Even if no specific openings are described below, please feel free to stop by the lab or email Dr Benninger to discuss options for projects and research training. 

​We have an open position for a postdoctoral fellow to work on developing research projects related to the role of cellular heterogeneity and intercellular communication in the regulation of cell signaling dynamics underlying hormone release from the islets of Langerhans and dysfunction in diabetes.
Apply here https://cu.taleo.net/careersection/2/jobdetail.ftl?job=21339&lang=en


​A number of research projects are available in our group for MS students involving islet or pancreas imaging. 

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Our lab is within the Barbara Davis center; a world leading diabetes center which provides state-of the-art care to children and adults with type 1 diabetes.

Barbara Davis center
1775 Aurora Ct. 
Aurora CO. 80045
(303) 724-6388
​richard.benninger@cuanschutz.edu

Come and see our lab's work!

2nd June '21

CIHR/NIDDK Heterogeneity of Diabetes: Beta-cells, phenotypes and precision medicine symposium

Virtual
​Richard Benninger will present 'Endocrine cell heterogeneity within the islet microenvironment' 

12th May '21

Mt Sinai School of Medicine

Virtual
​Richard Benninger will present 'Endocrine cell heterogeneity driving pancreatic islet function'